Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment

Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment

Background Interactions between immune and tumor cells are critical to determining cancer progression and response. In addition, preclinical prediction of immune-related drug efficacy is limited by interspecies differences between human and mouse, as well as inter-person germline and somatic variati...

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Bibliographic Details
Main Authors: Jan Martinek, Ryan C Fields, Scott Gettinger, Karolina Palucka, Katerina Politi, Jun Zhao, Ye Bi, Richard A Flavell, Frank Detterbeck, Obi Griffith, Liang Shan, Malachi Griffith, Michael Chiorazzi, Bradley Krasnick, Yunjiang Zheng, Keenan J Robbins, Rihao Qu, Gabriel Kaufmann, Zachary Skidmore, Melani Juric, Laura A Henze, Frederic Brösecke, Adam Adonyi, Esen Sefik, Jacqueline Mudd, S Peter Goedegebuure, Abimbola Oyedeji, Sofia Fertuzinhos, Rolando Garcia-Milian, Daniel Boffa, Andrew Dhanasopon, Justin Blasberg, Benjamin Judson, Yuval Kluger
Format: Article
Language:English
Published: BMJ Publishing Group 2023-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/7/e006921.full

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https://jitc.bmj.com/content/11/7/e006921.full

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