Tissue-specific endothelial cell heterogeneity contributes to unequal inflammatory responses
Abstract Endothelial cells (EC) coordinate vascular homeostasis and inflammation. In organ transplantation, EC are a direct alloimmune target. We posited that tissue specific heterogeneity of vascular EC may partly underlie the disparate organ-specific alloimmune risk. We examined the vascular endot...
Main Authors: | Hasitha Gunawardana, Tahmineh Romero, Ning Yao, Sebastiaan Heidt, Arend Mulder, David A. Elashoff, Nicole M. Valenzuela |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2021-01-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-80102-w |
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