The Mutation of the Genes Related to Neurovirulence in HSV-2 Produces an Attenuated Phenotype in Mice

The Mutation of the Genes Related to Neurovirulence in HSV-2 Produces an Attenuated Phenotype in Mice

HSV-2 (Herpes simplex virus type 2) is a critical viral agent that mainly causes genital herpes and life-long latent infection in the dorsal root ganglia. Gene modification via CRISPR/Cas9 Clustered regularly interspaced short palindromic repeat sequences/CRISPR associated 9) was used here to constr...

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Bibliographic Details
Main Authors: Lei Liu, Jishuai Cheng, Tangwei Mou, Ying Zhang, Xingli Xu, Jingjing Zhang, Xueqi Li, Xiao Feng, Xiangxiong Xu, Yun Liao, Shengtao Fan, Lichun Wang, Guorun Jiang, Qihan Li
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Viruses
Subjects:
<i>RL1-LAT-</i>HSV-2
<i>LAT-</i>HSV-2
infection
immune response
Online Access:https://www.mdpi.com/1999-4915/12/7/770

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https://www.mdpi.com/1999-4915/12/7/770

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