Quantitative Measurement and Thermodynamic Modeling of Fused Enhancers Support a Two-Tiered Mechanism for Interpreting Regulatory DNA

Quantitative Measurement and Thermodynamic Modeling of Fused Enhancers Support a Two-Tiered Mechanism for Interpreting Regulatory DNA

Computational models of enhancer function generally assume that transcription factors (TFs) exert their regulatory effects independently, modeling an enhancer as a “bag of sites.” These models fail on endogenous loci that harbor multiple enhancers, and a “two-tier” model appears better suited: in ea...

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Bibliographic Details
Main Authors: Md. Abul Hassan Samee, Tara Lydiard-Martin, Kelly M. Biette, Ben J. Vincent, Meghan D. Bragdon, Kelly B. Eckenrode, Zeba Wunderlich, Javier Estrada, Saurabh Sinha, Angela H. DePace
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
enhancer
fused enhancer
thermodynamic model
enhancer-level model
bag of sites model
quenching model
locus-level model
two-tier model
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313086

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http://www.sciencedirect.com/science/article/pii/S2211124717313086

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