Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis

Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis

In amyotrophic lateral sclerosis (ALS), neurodegeneration is characterized by distal axonopathy that begins at the distal axons, including the neuromuscular junctions, and progresses proximally in a “dying back” manner prior to the degeneration of cell bodies. However, the molecular mechanism for di...

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Bibliographic Details
Main Authors: Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima, Yoshio Goshima, Hideyuki Takeuchi, Hiroshi Doi, Fumio Nakamura, Fumiaki Tanaka
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Neurology
Subjects:
ALS
axon guidance
axonopathy
CRMP
motor neuron
neurofilament
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.994676/full

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https://www.frontiersin.org/articles/10.3389/fneur.2022.994676/full

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