A Potential Role of RUNX2- RUNT Domain in Modulating the Expression of Genes Involved in Bone Metastases: An In Vitro Study with Melanoma Cells

A Potential Role of RUNX2- RUNT Domain in Modulating the Expression of Genes Involved in Bone Metastases: An In Vitro Study with Melanoma Cells

Ectopic expression of RUNX2 has been reported in several tumors. In melanoma cells, the RUNT domain of RUNX2 increases cell proliferation and migration. Due to the strong link between RUNX2 and skeletal development, we hypothesized that the RUNT domain may be involved in the modulation of mechanisms...

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Bibliographic Details
Main Authors: Michela Deiana, Luca Dalle Carbonare, Michela Serena, Samuele Cheri, Simona Mutascio, Alberto Gandini, Giulio Innamorati, Pamela Lorenzi, Michela Cumerlato, Jessica Bertacco, Franco Antoniazzi, Maria Grazia Romanelli, Monica Mottes, Donato Zipeto, Maria Teresa Valenti
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
runx2
runt domain
pthrp
bone
metastasis
Online Access:https://www.mdpi.com/2073-4409/9/3/751

Internet

https://www.mdpi.com/2073-4409/9/3/751

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