Neutrophil extracellular trap biomarkers in aneurysmal subarachnoid hemorrhage: early decline of DNase 1 activity associated with delayed cerebral ischemia

Neutrophil extracellular trap biomarkers in aneurysmal subarachnoid hemorrhage: early decline of DNase 1 activity associated with delayed cerebral ischemia

IntroductionHigh-mobility group box 1 (HMGB1) protein is a critical mediator of neutrophil extracellular trap (NET) formation (NETosis). Myeloperoxidase (MPO)-DNA complexes, a biomarker of NETs, and HMGB1 have been associated with delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrh...

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Bibliographic Details
Main Authors: Philipp Hendrix, Jens Witsch, Valérie Spalart, Hauke Schneider, Joachim Oertel, Jürgen Geisel, Kimberly Martinod, Sina Hemmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Neurology
Subjects:
subarachnoid hemorrhage
intracranial aneurysm
neutrophil extracellular traps
cell-free DNA
DNase activity
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2024.1354224/full

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https://www.frontiersin.org/articles/10.3389/fneur.2024.1354224/full

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