Melatonin suppresses the antiviral immune response to EMCV infection through intracellular ATP deprivation caused by mitochondrial fragmentation

Melatonin suppresses the antiviral immune response to EMCV infection through intracellular ATP deprivation caused by mitochondrial fragmentation

Melatonin, a sleep hormone derived from the pineal gland, has an anti-inflammatory effect on the immune system in addition to modulating the brain nervous system. Previous studies have shown that melatonin suppresses signaling pathways downstream of multiple pattern recognition receptors on the inna...

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Bibliographic Details
Main Authors: Mariko Kikuchi, Miki Kadena, Haruka Fukamachi, Takashi Takaki, Shohei Matsui, Sumire Hoashi-Takiguchi, Hirobumi Morisaki, Nataša Trtić, Mina Mori, Mie Kurosawa, Momoe Itsumi, Takahiro Funatsu, Atsuo Sakurai, Seikou Shintani, Hiroki Kato, Takashi Fujita, Yasubumi Maruoka, Hirotaka Kuwata
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Heliyon
Subjects:
Innate immunity
Inflammation
Antiviral immunity
Melatonin
Neuro-immunology
Cytokines
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022024379

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http://www.sciencedirect.com/science/article/pii/S2405844022024379

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