Sensitive LC-MS/MS Methods for Amphotericin B Analysis in Cerebrospinal Fluid, Plasma, Plasma Ultrafiltrate, and Urine: Application to Clinical Pharmacokinetics

Sensitive LC-MS/MS Methods for Amphotericin B Analysis in Cerebrospinal Fluid, Plasma, Plasma Ultrafiltrate, and Urine: Application to Clinical Pharmacokinetics

Neurocryptococcosis, a meningoencephalitis caused by Cryptococcus spp, is treated with amphotericin B (AmB) combined with fluconazole. The integrity of the brain-blood barrier and the composition of the cerebrospinal fluid (CSF) may change due to infectious and/or inflammatory diseases such as neuro...

Full description

Bibliographic Details
Main Authors: Leandro Francisco Pippa, Maria Paula Marques, Anna Christina Tojal da Silva, Fernando Crivelenti Vilar, Tissiana Marques de Haes, Benedito Antônio Lopes da Fonseca, Roberto Martinez, Eduardo Barbosa Coelho, Lauro Wichert-Ana, Vera Lucia Lanchote
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Chemistry
Subjects:
amphotericin B
plasma
unbound fraction
urine
cerebrospinal fluid
LC-MS/MS
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.782131/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.782131/full

Similar Items