Circulating Th17 T cells at treatment onset predict autoimmune toxicity of PI3Kδ inhibitors

Circulating Th17 T cells at treatment onset predict autoimmune toxicity of PI3Kδ inhibitors

Abstract PI3Kδ inhibitors are approved for the therapy of B cell malignancies, but their clinical use has been limited by unpredictable autoimmune toxicity, despite promising efficacy and evidence that toxicity is associated with improved clinical outcomes. Prior phenotypic evaluation by CyTOF has i...

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Bibliographic Details
Main Authors: Deepti Gadi, Stephen P. Martindale, Pui Yan Chiu, Jasneet Khalsa, Pei-Hsuan Chen, Stacey M. Fernandes, Zixu Wang, Svitlana Tyekucheva, John-Hanson Machado, David C. Fisher, Philippe Armand, Matthew S. Davids, Scott Rodig, Barbara Sherry, Jennifer R. Brown
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-023-00788-9

Internet

https://doi.org/10.1038/s41408-023-00788-9

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