Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis?

Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis?

In this review, we summarize the evidence against direct stimulation of insulin-like growth factor 1 receptors (IGF1Rs) by autoantibodies in Graves’ orbitopathy (GO) pathogenesis. We describe a model of thyroid-stimulating hormone (TSH) receptor (TSHR)/IGF1R crosstalk and present evidence that obser...

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Bibliographic Details
Main Authors: Christine C. Krieger, Susanne Neumann, Marvin C. Gershengorn
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
IGF1R
TSHR
receptor crosstalk
Graves’ orbitopathy
IGF1R antibodies
TSHR antibodies
Online Access:https://www.mdpi.com/1422-0067/21/18/6561

Internet

https://www.mdpi.com/1422-0067/21/18/6561

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