Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in mice

Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in mice

Abstract Although emerging evidence shows that gut microbiota-mediated metabolic changes regulate intestinal pathogen invasions, little is known about whether and how gut microbiota-mediated metabolites affect pathogen infection in the distal organs. In this study, untargeted metabolomics was perfor...

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Bibliographic Details
Main Authors: Caijun Zhao, Keyi Wu, Haoyang Hao, Yihong Zhao, Lijuan Bao, Min Qiu, Yuhong He, Zhaoqi He, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-023-00374-8

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https://doi.org/10.1038/s41522-023-00374-8

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