Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in mice
Abstract Although emerging evidence shows that gut microbiota-mediated metabolic changes regulate intestinal pathogen invasions, little is known about whether and how gut microbiota-mediated metabolites affect pathogen infection in the distal organs. In this study, untargeted metabolomics was perfor...
Main Authors: | Caijun Zhao, Keyi Wu, Haoyang Hao, Yihong Zhao, Lijuan Bao, Min Qiu, Yuhong He, Zhaoqi He, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-02-01
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Series: | npj Biofilms and Microbiomes |
Online Access: | https://doi.org/10.1038/s41522-023-00374-8 |
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