TRPM4 Participates in Irradiation-Induced Aortic Valve Remodeling in Mice

TRPM4 Participates in Irradiation-Induced Aortic Valve Remodeling in Mice

Thoracic radiotherapy can lead to cardiac remodeling including valvular stenosis due to fibrosis and calcification. The monovalent non-selective cation channel TRPM4 is known to be involved in calcium handling and to participate in fibroblast transition to myofibroblasts, a phenomenon observed durin...

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Bibliographic Details
Main Authors: Harlyne Mpweme Bangando, Christophe Simard, Margaux Aize, Alexandre Lebrun, Alain Manrique, Romain Guinamard, on behalf of the STOP-AS Investigators
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
TRPM4
aortic valve
stenosis
fibrosis
Online Access:https://www.mdpi.com/2072-6694/14/18/4477

Internet

https://www.mdpi.com/2072-6694/14/18/4477

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