Abiraterone and MDV3100 inhibits the proliferation and promotes the apoptosis of prostate cancer cells through mitophagy

Abiraterone and MDV3100 inhibits the proliferation and promotes the apoptosis of prostate cancer cells through mitophagy

Abstract Background Abiraterone and MDV3100 are two effective anticancer agents for prostate cancer, however, the mechanism of their downstream action remains undefined. Methods A dual fluorescent biosensor plasmid was transfected in LNCaP cells to measure mitophagy. The DNA of LNCaP cells was extra...

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Bibliographic Details
Main Authors: Jingli Han, Junhua Zhang, Wei Zhang, Dalei Zhang, Ying Li, Jinsong Zhang, Yaqun Zhang, Tongxiang Diao, Luwei Cui, Wenqing Li, Fei Xiao, Ming Liu, Lihui Zou
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Cancer Cell International
Subjects:
Prostate cancer
Mitophagy
Abiraterone
MDV3100
Online Access:https://doi.org/10.1186/s12935-019-1021-9

Internet

https://doi.org/10.1186/s12935-019-1021-9

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