Fast-exchanging spirocyclic rhodamine probes for aptamer-based super-resolution RNA imaging

Fast-exchanging spirocyclic rhodamine probes for aptamer-based super-resolution RNA imaging

Abstract Live-cell RNA imaging with high spatial and temporal resolution remains a major challenge. Here we report the development of RhoBAST:SpyRho, a fluorescent light-up aptamer (FLAP) system ideally suited for visualizing RNAs in live or fixed cells with various advanced fluorescence microscopy...

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Bibliographic Details
Main Authors: Daniel Englert, Eva-Maria Burger, Franziska Grün, Mrigank S. Verma, Jens Lackner, Marko Lampe, Bastian Bühler, Janin Schokolowski, G. Ulrich Nienhaus, Andres Jäschke, Murat Sunbul
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39611-1

Internet

https://doi.org/10.1038/s41467-023-39611-1

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