IL-1β and TNFα Differentially Influence NF-κB Activity and FasL-Induced Apoptosis in Primary Murine Hepatocytes During LPS-Induced Inflammation

IL-1β and TNFα Differentially Influence NF-κB Activity and FasL-Induced Apoptosis in Primary Murine Hepatocytes During LPS-Induced Inflammation

Macrophage-derived cytokines largely influence the behavior of hepatocytes during an inflammatory response. We previously reported that both TNFα and IL-1β, which are released by macrophages upon LPS stimulation, affect Fas ligand (FasL)-induced apoptotic signaling. Whereas TNFα preincubation leads...

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Bibliographic Details
Main Authors: Julia Rex, Anna Lutz, Laura E. Faletti, Ute Albrecht, Maria Thomas, Johannes G. Bode, Christoph Borner, Oliver Sawodny, Irmgard Merfort
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Physiology
Subjects:
primary murine hepatocytes
macrophages
signaling
apoptosis
LPS-induced inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00117/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00117/full

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