Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease

Brain microglia and border-associated macrophages (BAMs) display distinct spatial, developmental, and phenotypic features. Although at steady state, the origins of distinct brain macrophages are well-documented, the dynamics of their replenishment in neurodegenerative disorders remain elusive, parti...

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Bibliographic Details
Main Authors: Xiaoting Wu, Takashi Saito, Takaomi C Saido, Anna M Barron, Christiane Ruedl
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/71879