Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis

Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis

Abstract Hexanucleotide repeat expansion of C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Synergies between loss of C9ORF72 functions and gain of toxicities from the repeat expansions contribute to C9ORF72-mediated pathogenesis. However, how l...

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Bibliographic Details
Main Authors: Wan Yun Ho, Sheeja Navakkode, Fujia Liu, Tuck Wah Soong, Shuo-Chien Ling
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis (ALS)
Frontotemporal dementia (FTD)
C9ORF72
Klotho
Longevity
Dentate gyrus, adult neurogenesis
Online Access:http://link.springer.com/article/10.1186/s40478-020-01030-4

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http://link.springer.com/article/10.1186/s40478-020-01030-4

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