Can APOE and MTHFR polymorphisms have an influence on the severity of cardiovascular manifestations in Italian Pseudoxanthoma elasticum affected patients?

Can APOE and MTHFR polymorphisms have an influence on the severity of cardiovascular manifestations in Italian Pseudoxanthoma elasticum affected patients?

Background: The clinical phenotype of Pseudoxanthoma elasticum (PXE) affected patients, although progressive with age, is very heterogeneous, even in the presence of identical ABCC6 mutations, thus suggesting the occurrence of modifier genes. Beside typical skin manifestations, the cardiovascular (C...

Full description

Bibliographic Details
Main Authors: Federica Boraldi, Sonia Costa, Claudio Rabacchi, Miriam Ciani, Olivier Vanakker, Daniela Quaglino
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Pseudoxanthoma elasticum
Skin-disease
Apolipoprotein E
Methylenetetrahydrofolate reductase
Cardiovascular
Online Access:http://www.sciencedirect.com/science/article/pii/S221442691400072X

Internet

http://www.sciencedirect.com/science/article/pii/S221442691400072X

Similar Items