Changes in Expression and Cellular Localization of Rat Skeletal Muscle ClC-1 Chloride Channel in Relation to Age, Myofiber Phenotype and PKC Modulation

Changes in Expression and Cellular Localization of Rat Skeletal Muscle ClC-1 Chloride Channel in Relation to Age, Myofiber Phenotype and PKC Modulation

The ClC-1 chloride channel 1 is important for muscle function as it stabilizes resting membrane potential and helps to repolarize the membrane after action potentials. We investigated the contribution of ClC-1 to adaptation of skeletal muscles to needs induced by the different stages of life. We ana...

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Bibliographic Details
Main Authors: Elena Conte, Adriano Fonzino, Antonio Cibelli, Vito De Benedictis, Paola Imbrici, Grazia Paola Nicchia, Sabata Pierno, Giulia Maria Camerino
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
chloride ion channel 1
ClC-1
protein kinase C (PCK)
muscle development
muscle aging
subcellular localization
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00714/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00714/full

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