Pubertal exposure to Microcystin-LR arrests spermatogonia proliferation by inducing DSB and inhibiting SIRT6 dependent DNA repair in vivo and in vitro

Pubertal exposure to Microcystin-LR arrests spermatogonia proliferation by inducing DSB and inhibiting SIRT6 dependent DNA repair in vivo and in vitro

The reproduction toxicity of pubertal exposure to Microcystin-LR (MC-LR) and the underlying mechanism needs to be further investigated. In the current study, pubertal male ICR mice were intraperitoneally injected with 2 μg/kg MC-LR for four weeks. Pubertal exposure to MC-LR decreased epididymal sper...

Full description

Bibliographic Details
Main Authors: Yu-lin Liu, Jia-yu Liu, Xin-xin Zhu, Jian-hua Wei, Shuang-ling Mi, Su-ya Liu, Xiu-liang Li, Wei-wei Zhang, Ling-li Zhao, Hua Wang, De-xiang Xu, Lan Gao
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Microcystin-LR (MC-LR)
Sirtuin 6 (SIRT6)
Poly[adenosine diphosphate (ADP)-ribose] polymerase 1 (PARP1)
DNA double strands break (DSB)
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324002677

Internet

http://www.sciencedirect.com/science/article/pii/S0147651324002677

Similar Items