Toll-like Receptor 4: Innate Immune Regulator of Neuroimmune and Neuroendocrine interactions in Stress and Major Depressive Disorder

Toll-like Receptor 4: Innate Immune Regulator of Neuroimmune and Neuroendocrine interactions in Stress and Major Depressive Disorder

Major depressive disorder (MDD) poses one of the highest disease burdens worldwide. Yet, current treatments targeting serotonergic and noradrenaline reuptake systems are insufficient to provide long-term relief from depressive symptoms in most patients, indicating the need for new treatment targets....

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Bibliographic Details
Main Authors: Jiajun eLiu, Femke eBuisman-Pijlman, Mark R Hutchinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Neuroscience
Subjects:
Depression
Toll-Like Receptor 4
stress
TLR4
neuroimmunology
HPA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00309/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00309/full

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