Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease

Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease

Summary: p53 and HSF1 are two major transcription factors involved in cell proliferation and apoptosis, whose dysregulation contributes to cancer and neurodegeneration. Contrary to most cancers, p53 is increased in Huntington’s disease (HD) and other neurodegenerative diseases, while HSF1 is decreas...

Full description

Bibliographic Details
Main Authors: Rachel H. Mansky, Erin A. Greguske, Dahyun Yu, Nicole Zarate, Taylor A. Intihar, Wei Tsai, Taylor G. Brown, Mackenzie N. Thayer, Kompal Kumar, Rocio Gomez-Pastor
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723002097

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723002097

Similar Items