A functional genetic toolbox for human tissue-derived organoids

A functional genetic toolbox for human tissue-derived organoids

Human organoid systems recapitulate key features of organs offering platforms for modelling developmental biology and disease. Tissue-derived organoids have been widely used to study the impact of extrinsic niche factors on stem cells. However, they are rarely used to study endogenous gene function...

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Bibliographic Details
Main Authors: Dawei Sun, Lewis Evans, Francesca Perrone, Vanesa Sokleva, Kyungtae Lim, Saba Rezakhani, Matthias Lutolf, Matthias Zilbauer, Emma L Rawlins
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
organoids
lung
CRISPR-Cas9
homologous gene targeting
inducible CRISPRi
CRISPRa
Online Access:https://elifesciences.org/articles/67886

Internet

https://elifesciences.org/articles/67886

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