Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands to Mediate Shiga Toxin and Serum Amyloid P Component Ternary Complex Formation

Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands to Mediate Shiga Toxin and Serum Amyloid P Component Ternary Complex Formation

Inhibition of AB5-type bacterial toxins can be achieved by heterobifunctional ligands (BAITs) that mediate assembly of supramolecular complexes involving the toxin’s pentameric cell membrane-binding subunit and an endogenous protein, serum amyloid P component, of the innate immune system. Effective...

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Bibliographic Details
Main Authors: Glen D. Armstrong, George L. Mulvey, Thomas P. Griener, Ravin Narain, Zhicheng Deng, Marya Ahmed, Joanna M. Sadowska, Eugenia Paszkiewicz, Pavel I. Kitov, David R. Bundle
Format: Article
Language:English
Published: MDPI AG 2011-08-01
Series:Toxins
Subjects:
E. coli O157:H7
multivalent inhibitors
Pk-trisaccharide
Gb3
Online Access:http://www.mdpi.com/2072-6651/3/9/1065/

Internet

http://www.mdpi.com/2072-6651/3/9/1065/

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