Repurposing Loperamide as an Anti-Infection Drug for the Treatment of Intracellular Bacterial Pathogens

Repurposing Loperamide as an Anti-Infection Drug for the Treatment of Intracellular Bacterial Pathogens

Infections caused by intracellular bacterial pathogens are difficult to treat since most antibiotics have low cell permeability and undergo rapid degradation within cells. The rapid development and dissemination of antimicrobial–resistant strains have exacerbated this dilemma. With the increasing kn...

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Bibliographic Details
Main Authors: Hongtao Liu, Siqi Li, Le Deng, Zhenxu Shi, Chenxiao Jiang, Jingyan Shu, Yuan Liu, Xuming Deng, Jianfeng Wang, Zhimin Guo, Jiazhang Qiu
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:Engineering
Subjects:
Intracellular bacteria
US Food and Drug Administration (FDA)-approved drugs
Drug repurposing
Loperamide
Autophagy
Glycoprotein nonmetastatic melanoma protein B
Online Access:http://www.sciencedirect.com/science/article/pii/S2095809924000560

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http://www.sciencedirect.com/science/article/pii/S2095809924000560

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