Quantitative phosphoproteomic analysis reveals unique cAMP signaling pools emanating from AC2 and AC6 in human airway smooth muscle cells

Quantitative phosphoproteomic analysis reveals unique cAMP signaling pools emanating from AC2 and AC6 in human airway smooth muscle cells

Human airway smooth muscle (HASM) is the primary target of ßAR agonists used to control airway hypercontractility in asthma and chronic obstructive pulmonary disease (COPD). ßAR agonists induce the production of cAMP by adenylyl cyclases (ACs), activate PKA and cause bronchodilation. Several other G...

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Bibliographic Details
Main Authors: Isabella Cattani-Cavalieri, Yue Li, Jordyn Margolis, Amy Bogard, Moom R. Roosan, Rennolds S. Ostrom
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Physiology
Subjects:
adenylyl cyclase
cAMP
g-protein coupled receptors
human airway smooth muscle
phosphoproteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1149063/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1149063/full

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