JAC4 Inhibits EGFR-Driven Lung Adenocarcinoma Growth and Metastasis through CTBP1-Mediated JWA/AMPK/NEDD4L/EGFR Axis

JAC4 Inhibits EGFR-Driven Lung Adenocarcinoma Growth and Metastasis through CTBP1-Mediated JWA/AMPK/NEDD4L/EGFR Axis

Lung adenocarcinoma (LUAD) is the most common lung cancer, with high mortality. As a tumor-suppressor gene, JWA plays an important role in blocking pan-tumor progression. JAC4, a small molecular-compound agonist, transcriptionally activates JWA expression both in vivo and in vitro. However, the dire...

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Bibliographic Details
Main Authors: Kun Ding, Xuqian Jiang, Zhangding Wang, Lu Zou, Jiahua Cui, Xiong Li, Chuanjun Shu, Aiping Li, Jianwei Zhou
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
EGFR
JAC4
JWA
NEDD4L
LUAD
ubiquitination
Online Access:https://www.mdpi.com/1422-0067/24/10/8794

Internet

https://www.mdpi.com/1422-0067/24/10/8794

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