TNFα counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes

TNFα counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes

TNFα-mediated signaling pathways play a pivotal role in the pathogenesis of inflammatory diseases such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) by promoting phagocyte inflammatory functions, notably cytokine release and reactive oxygen species (ROS) production by NOX2. In co...

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Bibliographic Details
Main Authors: Marwa Ben-Khemis, Dan Liu, Coralie Pintard, Zhuoyao Song, Margarita Hurtado-Nedelec, Jean-Claude Marie, Jamel El-Benna, Pham My-Chan Dang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Redox Biology
Subjects:
Monocytes
Reactive oxygen species
NOX2
TNFα
IL-10
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002999

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http://www.sciencedirect.com/science/article/pii/S2213231723002999

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