Copine7 deficiency leads to hepatic fat accumulation via mitochondrial dysfunction

Copine7 deficiency leads to hepatic fat accumulation via mitochondrial dysfunction

Objective: Mitochondrial dysfunction affects hepatic lipid homeostasis and promotes ROS generation. Copine7 (CPNE7) belongs to the ubiquitous copine family of calcium-dependent phospholipid binding proteins. CPNE7 has a high calcium ion binding affinity and the capacity to scavenge reactive oxygen s...

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Bibliographic Details
Main Authors: Geumbit Hwang, Hyejin Seo, Joo-Cheol Park
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
Copine7
fatty liver
Reactive oxygen species
Lipid metabolism
Mitochondrial dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023088849

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http://www.sciencedirect.com/science/article/pii/S2405844023088849

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