Yes-associated protein promotes endothelial-to-mesenchymal transition of endothelial cells in choroidal neovascularization fibrosis

Yes-associated protein promotes endothelial-to-mesenchymal transition of endothelial cells in choroidal neovascularization fibrosis

AIM: To reveal whether and how Yes-associated protein (YAP) promotes the occurrence of subretinal fibrosis in age-related macular degeneration (AMD). METHODS: Cobalt chloride (CoCl2) was used in primary human umbilical vein endothelial cells (HUVECs) to induce hypoxia in vitro. Eight-week-old male C...

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Bibliographic Details
Main Authors: Rong Zou, Yi-Fan Feng, Ya-Hui Xu, Min-Qian Shen, Xi Zhang, Yuan-Zhi Yuan
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2022-05-01
Series:International Journal of Ophthalmology
Subjects:
endothelial-to-mesenchymal transition
yes-associated protein
hypoxia-inducible factor-1α
choroidal neovascularization
age-related macular degeneration
Online Access:http://ies.ijo.cn/en_publish/2022/5/20220503.pdf

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http://ies.ijo.cn/en_publish/2022/5/20220503.pdf

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