Identification of plasminogen-binding sites in Streptococcus suis enolase that contribute to bacterial translocation across the blood-brain barrier

Identification of plasminogen-binding sites in Streptococcus suis enolase that contribute to bacterial translocation across the blood-brain barrier

Streptococcus suis is an emerging zoonotic pathogen that can cause invasive disease commonly associated with meningitis in pigs and humans. To cause meningitis, S. suis must cross the blood-brain barrier (BBB) comprising blood vessels that vascularize the central nervous system (CNS). The BBB is hig...

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Bibliographic Details
Main Authors: Tiantong Zhao, Alex Gussak, Bart van der Hee, Sylvia Brugman, Peter van Baarlen, Jerry M. Wells
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Streptococcus suis
blood-brain barrier
enolase
plasmin(ogen)
extracellular matrix
CRISPR/Cas9
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1356628/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2024.1356628/full

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