Ehrlich Tumor Induces TRPV1-Dependent Evoked and Non-Evoked Pain-like Behavior in Mice

Ehrlich Tumor Induces TRPV1-Dependent Evoked and Non-Evoked Pain-like Behavior in Mice

We standardized a model by injecting Ehrlich tumor cells into the paw to evaluate cancer pain mechanisms and pharmacological treatments. Opioid treatment, but not cyclooxygenase inhibitor or tricyclic antidepressant treatments reduces Ehrlich tumor pain. To best use this model for drug screening it...

Full description

Bibliographic Details
Main Authors: Mariana M. Bertozzi, Telma Saraiva-Santos, Tiago H. Zaninelli, Felipe A. Pinho-Ribeiro, Victor Fattori, Larissa Staurengo-Ferrari, Camila R. Ferraz, Talita P. Domiciano, Cassia Calixto-Campos, Sergio M. Borghi, Ana C. Zarpelon, Thiago M. Cunha, Rubia Casagrande, Waldiceu A. Verri
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Brain Sciences
Subjects:
AMG9810
calcium imaging
cancer pain
dorsal root ganglia
Ehrlich tumor
mechanical hyperalgesia
Online Access:https://www.mdpi.com/2076-3425/12/9/1247

Internet

https://www.mdpi.com/2076-3425/12/9/1247

Similar Items