hTERT Downregulation Attenuates Resistance to DOX, Impairs FAK-Mediated Adhesion, and Leads to Autophagy Induction in Breast Cancer Cells

hTERT Downregulation Attenuates Resistance to DOX, Impairs FAK-Mediated Adhesion, and Leads to Autophagy Induction in Breast Cancer Cells

Telomerase is known to contribute to telomere maintenance and to provide cancer cell immortality. However, numerous reports are showing that the function of the enzyme goes far beyond chromosome ends. The study aimed to explore how telomerase downregulation in MCF7 and MDA-MB-231 breast cancer cells...

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Bibliographic Details
Main Authors: Aleksandra Romaniuk-Drapała, Ewa Totoń, Natalia Konieczna, Marta Machnik, Wojciech Barczak, Dagmar Kowal, Przemysław Kopczyński, Mariusz Kaczmarek, Błażej Rubiś
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
hTERT
RNAi
adhesion
migration
senescence
autophagy
Online Access:https://www.mdpi.com/2073-4409/10/4/867

Internet

https://www.mdpi.com/2073-4409/10/4/867

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