Genetic Alteration Analysis of IDH1, IDH2, CDKN2A, MYB and MYBL1 in Pediatric Low-Grade Gliomas

Genetic Alteration Analysis of IDH1, IDH2, CDKN2A, MYB and MYBL1 in Pediatric Low-Grade Gliomas

ObjectiveTo investigate pediatric low-grade gliomas for alterations in IDH1, IDH2, CDKN2A, MYB, and MYBL1.Materials and MethodsDNA and RNA were extracted from 62 pediatric gliomas. Molecular methods included PCR, RT-PCR, and RNA sequencing; Sanger sequencing was used for validation.ResultsAnalysis f...

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Bibliographic Details
Main Authors: Orit Barinfeld, Alon Zahavi, Shirel Weiss, Helen Toledano, Shalom Michowiz, Nitza Goldenberg-Cohen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Surgery
Subjects:
glioma
pediatric
molecular
IDH1
MYB
MYBL1
Online Access:https://www.frontiersin.org/articles/10.3389/fsurg.2022.880048/full

Internet

https://www.frontiersin.org/articles/10.3389/fsurg.2022.880048/full

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