A draft map of the mouse pluripotent stem cell spatial proteome
The spatial location of proteins within a cell is a key element of protein function. Here the authors describe hyperLOPIT—a proteomics workflow that allows the simultaneous assignment of thousands of proteins to subcellular niches with high resolution—and apply it to mouse pluripotent stem cells....
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms9992 |
| _version_ | 1819194781911220224 |
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| author | Andy Christoforou Claire M. Mulvey Lisa M. Breckels Aikaterini Geladaki Tracey Hurrell Penelope C. Hayward Thomas Naake Laurent Gatto Rosa Viner Alfonso Martinez Arias Kathryn S. Lilley |
| author_facet | Andy Christoforou Claire M. Mulvey Lisa M. Breckels Aikaterini Geladaki Tracey Hurrell Penelope C. Hayward Thomas Naake Laurent Gatto Rosa Viner Alfonso Martinez Arias Kathryn S. Lilley |
| author_sort | Andy Christoforou |
| collection | DOAJ |
| description | The spatial location of proteins within a cell is a key element of protein function. Here the authors describe hyperLOPIT—a proteomics workflow that allows the simultaneous assignment of thousands of proteins to subcellular niches with high resolution—and apply it to mouse pluripotent stem cells. |
| first_indexed | 2024-12-23T02:02:20Z |
| format | Article |
| id | doaj.art-94b699fb21c4417090182a6c8cb87d48 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:02:20Z |
| publishDate | 2016-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-94b699fb21c4417090182a6c8cb87d482022-12-21T18:03:58ZengNature PortfolioNature Communications2041-17232016-01-017111210.1038/ncomms9992A draft map of the mouse pluripotent stem cell spatial proteomeAndy Christoforou0Claire M. Mulvey1Lisa M. Breckels2Aikaterini Geladaki3Tracey Hurrell4Penelope C. Hayward5Thomas Naake6Laurent Gatto7Rosa Viner8Alfonso Martinez Arias9Kathryn S. Lilley10Department of Biochemistry, Cambridge Centre for Proteomics, University of CambridgeDepartment of Biochemistry, Cambridge Centre for Proteomics, University of CambridgeDepartment of Biochemistry, Cambridge Centre for Proteomics, University of CambridgeDepartment of Biochemistry, Cambridge Centre for Proteomics, University of CambridgeDepartment of Biochemistry, Cambridge Centre for Proteomics, University of CambridgeDepartment of Genetics, University of CambridgeDepartment of Biochemistry, Cambridge Centre for Proteomics, University of CambridgeDepartment of Biochemistry, Cambridge Centre for Proteomics, University of CambridgeThermo Fisher ScientificDepartment of Genetics, University of CambridgeDepartment of Biochemistry, Cambridge Centre for Proteomics, University of CambridgeThe spatial location of proteins within a cell is a key element of protein function. Here the authors describe hyperLOPIT—a proteomics workflow that allows the simultaneous assignment of thousands of proteins to subcellular niches with high resolution—and apply it to mouse pluripotent stem cells.https://doi.org/10.1038/ncomms9992 |
| spellingShingle | Andy Christoforou Claire M. Mulvey Lisa M. Breckels Aikaterini Geladaki Tracey Hurrell Penelope C. Hayward Thomas Naake Laurent Gatto Rosa Viner Alfonso Martinez Arias Kathryn S. Lilley A draft map of the mouse pluripotent stem cell spatial proteome Nature Communications |
| title | A draft map of the mouse pluripotent stem cell spatial proteome |
| title_full | A draft map of the mouse pluripotent stem cell spatial proteome |
| title_fullStr | A draft map of the mouse pluripotent stem cell spatial proteome |
| title_full_unstemmed | A draft map of the mouse pluripotent stem cell spatial proteome |
| title_short | A draft map of the mouse pluripotent stem cell spatial proteome |
| title_sort | draft map of the mouse pluripotent stem cell spatial proteome |
| url | https://doi.org/10.1038/ncomms9992 |
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