Research on the Efficacy of Ganpu Vine Tea in Inhibiting Uric Acid Production
Ganpu vine tea is a new type of health care citrus fruit tea made from citrus shell, Pu-er tea, and vine tea baked as raw materials. In this study, the in vitro uric acid synthase inhibition system and hyperuric acid cell model were constructed to appraise the uric acid lowering efficacy of Ganpu vi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/6/704 |
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| author | Zhi-Xu Zhang Run-Ming Mo Dong-Bo Liu Yi-Song Liu Cong-Hui Liu Yong-Shen Li Zhong-Hua Liu Dan Qin |
| author_facet | Zhi-Xu Zhang Run-Ming Mo Dong-Bo Liu Yi-Song Liu Cong-Hui Liu Yong-Shen Li Zhong-Hua Liu Dan Qin |
| author_sort | Zhi-Xu Zhang |
| collection | DOAJ |
| description | Ganpu vine tea is a new type of health care citrus fruit tea made from citrus shell, Pu-er tea, and vine tea baked as raw materials. In this study, the in vitro uric acid synthase inhibition system and hyperuric acid cell model were constructed to appraise the uric acid lowering efficacy of Ganpu vine tea, traditional Ganpu tea, and vine tea. Results showed that in the uric acid synthase inhibition system, the aqueous extract can inhibite the puric metabolically related enzymes, such as adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and xanthine oxidase (XOD). The ability of the aqueous extract to inhibit the above enzyme was as follows: vine tea > Ganpu vine tea > Ganpu tea; all teas had a strong effect on XOD inhibition. The hyperuric acid cell model test showed that the aqueous extract inhibited uric acid production through accumulating inosine and hypoxanthine and hindering xanthine synthesis. The uric acid reductive ability was as follows: Vine tea > Ganpu vine tea > Ganpu tea. The inhibition of enzymes related to uric acid synthesis and the inhibition of uric acid production were significantly enhanced through adding vine tea to Ganpu tea. It also shows that flavonoids are the main factor driving this ability because they are the main active ingredients in these botanical drinks. |
| first_indexed | 2024-03-11T02:10:33Z |
| format | Article |
| id | doaj.art-94b6cc2377ea4a20b31d669b56a8effc |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T02:10:33Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-94b6cc2377ea4a20b31d669b56a8effc2023-11-18T11:34:33ZengMDPI AGMetabolites2218-19892023-05-0113670410.3390/metabo13060704Research on the Efficacy of Ganpu Vine Tea in Inhibiting Uric Acid ProductionZhi-Xu Zhang0Run-Ming Mo1Dong-Bo Liu2Yi-Song Liu3Cong-Hui Liu4Yong-Shen Li5Zhong-Hua Liu6Dan Qin7Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, ChinaHunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, ChinaHunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, ChinaHunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, ChinaHunan Kangqi 100 Biotechnology Ltd., Zhuzhou 412205, ChinaHunan Kangqi 100 Biotechnology Ltd., Zhuzhou 412205, ChinaHunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, ChinaHunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, ChinaGanpu vine tea is a new type of health care citrus fruit tea made from citrus shell, Pu-er tea, and vine tea baked as raw materials. In this study, the in vitro uric acid synthase inhibition system and hyperuric acid cell model were constructed to appraise the uric acid lowering efficacy of Ganpu vine tea, traditional Ganpu tea, and vine tea. Results showed that in the uric acid synthase inhibition system, the aqueous extract can inhibite the puric metabolically related enzymes, such as adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and xanthine oxidase (XOD). The ability of the aqueous extract to inhibit the above enzyme was as follows: vine tea > Ganpu vine tea > Ganpu tea; all teas had a strong effect on XOD inhibition. The hyperuric acid cell model test showed that the aqueous extract inhibited uric acid production through accumulating inosine and hypoxanthine and hindering xanthine synthesis. The uric acid reductive ability was as follows: Vine tea > Ganpu vine tea > Ganpu tea. The inhibition of enzymes related to uric acid synthesis and the inhibition of uric acid production were significantly enhanced through adding vine tea to Ganpu tea. It also shows that flavonoids are the main factor driving this ability because they are the main active ingredients in these botanical drinks.https://www.mdpi.com/2218-1989/13/6/704Ganpu vine teaxanthine oxidaseuric acidin vitro enzyme inhibition modelcellular model |
| spellingShingle | Zhi-Xu Zhang Run-Ming Mo Dong-Bo Liu Yi-Song Liu Cong-Hui Liu Yong-Shen Li Zhong-Hua Liu Dan Qin Research on the Efficacy of Ganpu Vine Tea in Inhibiting Uric Acid Production Metabolites Ganpu vine tea xanthine oxidase uric acid in vitro enzyme inhibition model cellular model |
| title | Research on the Efficacy of Ganpu Vine Tea in Inhibiting Uric Acid Production |
| title_full | Research on the Efficacy of Ganpu Vine Tea in Inhibiting Uric Acid Production |
| title_fullStr | Research on the Efficacy of Ganpu Vine Tea in Inhibiting Uric Acid Production |
| title_full_unstemmed | Research on the Efficacy of Ganpu Vine Tea in Inhibiting Uric Acid Production |
| title_short | Research on the Efficacy of Ganpu Vine Tea in Inhibiting Uric Acid Production |
| title_sort | research on the efficacy of ganpu vine tea in inhibiting uric acid production |
| topic | Ganpu vine tea xanthine oxidase uric acid in vitro enzyme inhibition model cellular model |
| url | https://www.mdpi.com/2218-1989/13/6/704 |
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