Macrophage Plasticity and Function in the Lung Tumour Microenvironment Revealed in 3D Heterotypic Spheroid and Explant Models

Macrophage Plasticity and Function in the Lung Tumour Microenvironment Revealed in 3D Heterotypic Spheroid and Explant Models

In non-small cell lung cancer (NSCLC), stroma-resident and tumour-infiltrating macrophages may facilitate an immunosuppressive tumour microenvironment (TME) and hamper immunotherapeutic responses. Analysis of tumour-associated macrophage (TAM) plasticity in NSCLC is largely lacking. We established a...

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Bibliographic Details
Main Authors: Lauren Evans, Kate Milward, Richard Attanoos, Aled Clayton, Rachel Errington, Zsuzsanna Tabi
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomedicines
Subjects:
heterotypic spheroids
myeloid cells
NSCLC
tumour explants
tumour microenvironment
Online Access:https://www.mdpi.com/2227-9059/9/3/302

Internet

https://www.mdpi.com/2227-9059/9/3/302

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