Absence of endothelial α5β1 integrin triggers early onset of experimental autoimmune encephalomyelitis due to reduced vascular remodeling and compromised vascular integrity

Absence of endothelial α5β1 integrin triggers early onset of experimental autoimmune encephalomyelitis due to reduced vascular remodeling and compromised vascular integrity

Abstract Early in the development of multiple sclerosis (MS) and its mouse model experimental autoimmune encephalomyelitis (EAE), vascular integrity is compromised. This is accompanied by a marked vascular remodeling response, though it is currently unclear whether this is an adaptive vascular repai...

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Bibliographic Details
Main Authors: Ravi Kant, Sebok K. Halder, Gregory J. Bix, Richard Milner
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Acta Neuropathologica Communications
Subjects:
Endothelial
Extracellular matrix
Fibronectin
Integrin
Experimental autoimmune encephalomyelitis
Blood-brain barrier
Online Access:http://link.springer.com/article/10.1186/s40478-019-0659-9

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http://link.springer.com/article/10.1186/s40478-019-0659-9

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