Comparison of methanol fixation versus cryopreservation of the placenta for metabolomics analysis

Abstract Methods for collection of placental tissue at room temperature for metabolic profiling are described. Specimens were excised from the maternal side of the placenta and immediately flash frozen or fixed and stored for 1, 6, 12, 24, or 48 h in 80% methanol. Untargeted metabolic profiling was...

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Bibliographic Details
Main Authors: Jennifer K. Straughen, Alexandra R. Sitarik, A. Daniel Jones, Jia Li, Ghassan Allo, Carolyn Salafia, Andrea E. Cassidy-Bushrow, Nigel Paneth
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-31287-3