The cytotoxicity effect of 7-hydroxy-3,4-dihydrocadalene from Heterotheca inuloides and semisynthetic cadalenes derivates towards breast cancer cells: involvement of oxidative stress-mediated apoptosis

Background Heterotheca inuloides, traditionally employed in Mexico, has demonstrated anticancer activities. Although it has been proven that the cytotoxic effect is attributed to cadinane-type sesquiterpenes such as 7-hydroxy-3,4-dihydrocadalene, the mechanism of action by which these agents act in...

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Main Authors: Alan Mendoza-Fuentes, Elena González-Burgos, Omar Emiliano Aparicio Trejo, Guillermo Delgado-Lamas, José Luis Rodríguez-Chávez, José Pedraza-Chaverri, M. Pilar Gómez-Serranillos, Daniela Araiza-Olivera
Format: Article
Language:English
Published: PeerJ Inc. 2023-06-01
Series:PeerJ
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Online Access:https://peerj.com/articles/15586.pdf