Alternative end-joining in BCR gene rearrangements and translocations

Alternative end-joining in BCR gene rearrangements and translocations

Programmed DNA double-strand breaks (DSBs) occur during antigen receptor gene recombination, namely V(D)J recombination in developing B lymphocytes and class switch recombination (CSR) in mature B cells. Repair of these DSBs by classical end-joining (c-NHEJ) enables the generation of diverse BCR rep...

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Bibliographic Details
Main Authors: Bai Wanyu, Zhao Bo, Gu Mingyu, Dong Junchao
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-05-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
classical nonhomologous end-joining
alternative end-joining
V(D)J recombination
chromosomal translocation
DSB end resection
endonuclease
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022051

Internet

https://www.sciengine.com/doi/10.3724/abbs.2022051

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