Alternative end-joining in BCR gene rearrangements and translocations
Programmed DNA double-strand breaks (DSBs) occur during antigen receptor gene recombination, namely V(D)J recombination in developing B lymphocytes and class switch recombination (CSR) in mature B cells. Repair of these DSBs by classical end-joining (c-NHEJ) enables the generation of diverse BCR rep...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2022-05-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2022051 |
| _version_ | 1797635424327303168 |
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| author | Bai Wanyu Zhao Bo Gu Mingyu Dong Junchao |
| author_facet | Bai Wanyu Zhao Bo Gu Mingyu Dong Junchao |
| author_sort | Bai Wanyu |
| collection | DOAJ |
| description | Programmed DNA double-strand breaks (DSBs) occur during antigen receptor gene recombination, namely V(D)J recombination in developing B lymphocytes and class switch recombination (CSR) in mature B cells. Repair of these DSBs by classical end-joining (c-NHEJ) enables the generation of diverse BCR repertoires for efficient humoral immunity. Deletion of or mutation in c-NHEJ genes in mice and humans confer various degrees of primary immune deficiency and predisposition to lymphoid malignancies that often harbor oncogenic chromosomal translocations. In the absence of c-NHEJ, alternative end-joining (A-EJ) catalyzes robust CSR and to a much lesser extent, V(D)J recombination, but the mechanisms of A-EJ are only poorly defined. In this review, we introduce recent advances in the understanding of A-EJ in the context of V(D)J recombination and CSR with emphases on DSB end processing, DNA polymerases and ligases, and discuss the implications of A-EJ to lymphoid development and chromosomal translocations. |
| first_indexed | 2024-03-11T12:20:57Z |
| format | Article |
| id | doaj.art-94be0b5cab994013bfa594fe6f2f014e |
| institution | Directory Open Access Journal |
| issn | 1672-9145 |
| language | English |
| last_indexed | 2024-03-11T12:20:57Z |
| publishDate | 2022-05-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj.art-94be0b5cab994013bfa594fe6f2f014e2023-11-07T00:58:31ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452022-05-015478279510.3724/abbs.202205120d259ccAlternative end-joining in BCR gene rearrangements and translocationsBai Wanyu0Zhao Bo1Gu Mingyu2Dong Junchao3["Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China","Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China"]["Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China","Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China"]["Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China","Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China"]["Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China","Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China"]Programmed DNA double-strand breaks (DSBs) occur during antigen receptor gene recombination, namely V(D)J recombination in developing B lymphocytes and class switch recombination (CSR) in mature B cells. Repair of these DSBs by classical end-joining (c-NHEJ) enables the generation of diverse BCR repertoires for efficient humoral immunity. Deletion of or mutation in c-NHEJ genes in mice and humans confer various degrees of primary immune deficiency and predisposition to lymphoid malignancies that often harbor oncogenic chromosomal translocations. In the absence of c-NHEJ, alternative end-joining (A-EJ) catalyzes robust CSR and to a much lesser extent, V(D)J recombination, but the mechanisms of A-EJ are only poorly defined. In this review, we introduce recent advances in the understanding of A-EJ in the context of V(D)J recombination and CSR with emphases on DSB end processing, DNA polymerases and ligases, and discuss the implications of A-EJ to lymphoid development and chromosomal translocations.https://www.sciengine.com/doi/10.3724/abbs.2022051classical nonhomologous end-joiningalternative end-joiningV(D)J recombinationchromosomal translocationDSB end resectionendonuclease |
| spellingShingle | Bai Wanyu Zhao Bo Gu Mingyu Dong Junchao Alternative end-joining in BCR gene rearrangements and translocations Acta Biochimica et Biophysica Sinica classical nonhomologous end-joining alternative end-joining V(D)J recombination chromosomal translocation DSB end resection endonuclease |
| title | Alternative end-joining in BCR gene rearrangements and translocations |
| title_full | Alternative end-joining in BCR gene rearrangements and translocations |
| title_fullStr | Alternative end-joining in BCR gene rearrangements and translocations |
| title_full_unstemmed | Alternative end-joining in BCR gene rearrangements and translocations |
| title_short | Alternative end-joining in BCR gene rearrangements and translocations |
| title_sort | alternative end joining in bcr gene rearrangements and translocations |
| topic | classical nonhomologous end-joining alternative end-joining V(D)J recombination chromosomal translocation DSB end resection endonuclease |
| url | https://www.sciengine.com/doi/10.3724/abbs.2022051 |
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