RUN(X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome

RUN(X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome

Abstract Background RUNX1 is a transcription factor and a master regulator for the specification of the hematopoietic lineage during embryogenesis and postnatal megakaryopoiesis. Mutations and rearrangements on RUNX1 are key drivers of hematological malignancies. In humans, this gene is localized to...

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Bibliographic Details
Main Authors: Esteban J. Rozen, Christopher D. Ozeroff, Mary Ann Allen
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Human Genomics
Subjects:
RUNX1
Trisomy 21
Down syndrome
Transcription
Alternative splicing
Online Access:https://doi.org/10.1186/s40246-023-00531-2

Internet

https://doi.org/10.1186/s40246-023-00531-2

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