CSF3R T618I Collaborates With RUNX1-RUNX1T1 to Expand Hematopoietic Progenitors and Sensitizes to GLI Inhibition

CSF3R T618I Collaborates With RUNX1-RUNX1T1 to Expand Hematopoietic Progenitors and Sensitizes to GLI Inhibition

Activating colony-stimulating factor-3 receptor gene (CSF3R) mutations are recurrent in acute myeloid leukemia (AML) with t(8;21) translocation. However, the nature of oncogenic collaboration between alterations of CSF3R and the t(8;21) associated RUNX1-RUNX1T1 fusion remains unclear. In CD34+ hemat...

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Bibliographic Details
Main Authors: Anja S. Swoboda, Vanessa C. Arfelli, Anna Danese, Roland Windisch, Paul Kerbs, Enric Redondo Monte, Johannes W. Bagnoli, Linping Chen-Wichmann, Alessandra Caroleo, Monica Cusan, Stefan Krebs, Helmut Blum, Michael Sterr, Wolfgang Enard, Tobias Herold, Maria Colomé-Tatché, Christian Wichmann, Philipp A. Greif
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000958

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http://journals.lww.com/10.1097/HS9.0000000000000958

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