Assessing the efficacy and safety of mycophenolate mofetil versus azathioprine in patients with autoimmune hepatitis (CAMARO trial): study protocol for a randomised controlled trial

Assessing the efficacy and safety of mycophenolate mofetil versus azathioprine in patients with autoimmune hepatitis (CAMARO trial): study protocol for a randomised controlled trial

Abstract Background Currently, the standard therapy for autoimmune hepatitis (AIH) consists of a combination of prednisolone and azathioprine. However, 15% of patients are intolerant to azathioprine which necessitates cessation of azathioprine or changes in therapy. In addition, not all patients ach...

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Main Authors: Romée J. A. L. M. Snijders, Anna E. C. Stoelinga, Tom J. G. Gevers, Simon Pape, Maaike Biewenga, Robert C. Verdonk, Hendrik J. M. de Jonge, Jan Maarten Vrolijk, Sjoerd F. Bakker, Thomas Vanwolleghem, Ynto S. de Boer, Martine A. M. C. Baven Pronk, Ulrich H. W. Beuers, Adriaan J. van der Meer, Nicole M. F. van Gerven, Marijn G. M. Sijtsma, Bart J. Verwer, Ingrid A. M. Gisbertz, Maartje Bartelink, Floris F. van den Brand, Kerem Sebib Korkmaz, Aad P. van den Berg, Maureen M. J. Guichelaar, Khalida Soufidi, Amar D. Levens, Bart van Hoek, Joost P. H. Drenth, on behalf of the Dutch Autoimmune Hepatitis Working Group
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Trials
Subjects:
Autoimmune hepatitis
Azathioprine
Mycophenolate mofetil
First-line treatment
Induction therapy
Randomized controlled trial
Online Access:https://doi.org/10.1186/s13063-022-06890-w

Internet

https://doi.org/10.1186/s13063-022-06890-w

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