Machine Learning Analysis of Naïve B-Cell Receptor Repertoires Stratifies Celiac Disease Patients and Controls

Machine Learning Analysis of Naïve B-Cell Receptor Repertoires Stratifies Celiac Disease Patients and Controls

Celiac disease (CeD) is a common autoimmune disorder caused by an abnormal immune response to dietary gluten proteins. The disease has high heritability. HLA is the major susceptibility factor, and the HLA effect is mediated via presentation of deamidated gluten peptides by disease-associated HLA-DQ...

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Bibliographic Details
Main Authors: Or Shemesh, Pazit Polak, Knut E. A. Lundin, Ludvig M. Sollid, Gur Yaari
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
celiac disease
BCR repertoire
immune response
machine learning
naïve B-cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.627813/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.627813/full

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