Transcriptomics-based analysis of co-exposure of cadmium (Cd) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) indicates mitochondrial dysfunction induces NLRP3 inflammasome and inflammatory cell death in renal tubular epithelial cells

Transcriptomics-based analysis of co-exposure of cadmium (Cd) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) indicates mitochondrial dysfunction induces NLRP3 inflammasome and inflammatory cell death in renal tubular epithelial cells

Environmental pollution often releases multiple contaminants resulting in as yet largely uncharacterized additive toxicities. Cadmium (Cd) is a widespread pollutant that induces nephrotoxicity in animal models and humans. However, the combined effect of Cd in causing nephrotoxicity with 2,2',4,...

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Bibliographic Details
Main Authors: Yi Zhang, Bo Hu, Xiaolan Qian, Guangtao Xu, Xin Jin, Deqing Chen, Jie Tang, Long Xu
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Cadmium
BDE-47
Transcriptomics
Mitochondrial dysfunction
Inflammatory cell death
Renal tubular epithelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322006303

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http://www.sciencedirect.com/science/article/pii/S0147651322006303

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