Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration

Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration

Abstract There is emerging evidence about the predictive role of homologous recombination deficiency (HRD), but this is less defined in gastrointestinal (GI) and thoracic malignancies. We reviewed whole genome (WGS) and transcriptomic (RNA-Seq) data from advanced GI and thoracic cancers in the Perso...

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Main Authors: Erica S. Tsang, Veronika Csizmok, Laura M. Williamson, Erin Pleasance, James T. Topham, Joanna M. Karasinska, Emma Titmuss, Intan Schrader, Stephen Yip, Basile Tessier-Cloutier, Karen Mungall, Tony Ng, Sophie Sun, Howard J. Lim, Jonathan M. Loree, Janessa Laskin, Marco A. Marra, Steven J. M. Jones, David F. Schaeffer, Daniel J. Renouf
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-023-00368-x

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https://doi.org/10.1038/s41698-023-00368-x

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